1. Package leaflet: Information for the user. AVONEX 30 micrograms/ ml solution for Injection. (Interferon beta-1a). Pre-filled syringe. Read all of this leaflet. Package leaflet: Information for the user. AVONEX 30 micrograms/ml solution for injection in pre-filled pen. (Interferon beta-1a). Pre-filled pen. Read all of this. Formal hepatic drug metabolism studies with AVONEX PS/AVONEX PEN in This leaflet is part III of a three-part “Product Monograph”.
|Published (Last):||8 January 2015|
|PDF File Size:||14.45 Mb|
|ePub File Size:||5.41 Mb|
|Price:||Free* [*Free Regsitration Required]|
Major Consider the potential risk of interferon beta products inserf in combination with known hepatotoxic drugs or other products e. Inject subcutaneously using a dart-like motion into the outer surface of the upper arm, abdomen, avonrx, or buttock. Both interferon beta and interferon alpha are encoded on chromosome 9.
These side effects are very rare. Tell any other doctors, dentists and pharmacists who treat you that you are using this medicine. Insdrt clinical trials with interferon beta-1a there were 2 spontaneous abortions observed and 5 fetuses carried to term among 7 women in the treatment groups. Soreness, redness or bruising at the injection site. The potential of additive effects from multiple drugs or other hepatotoxic agents has not been determined; however, caution is recommended if interferon beta-1a is given concurrently with any hepatotoxic agents.
Avonex CMI | Mobile
If a dose is missed, administer it as soon as possible. Hold the syringe so the cap is facing down and the 0.
Used to treat depression. In another study, a negative HCV RNA inxert weeks after therapy cessation was obtained in 11 of 51 patients who got 22 mcg subcutaneously daily for 24 weeks and in 14 of 51 patients who also got ribavirin 1, mg PO daily for weight less than 70 kg and 1, mg PO daily for weight 70 kg or more.
The serum elimination half-life was 69 hours. Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate: Specific guidelines for dosage adjustments in hepatic impairment are not available; it appears that no dosage adjustments are needed. Discontinuation of lamivudine should be considered as medically appropriate.
After counting to 10, pull the Pen straight out of the skin.
The manufacturer of Avonex offers free training on intramuscular injection administration for patients and their health care partners. Hold Pen with one hand and using other hand, hold onto the injector shield grooved area tightly and quickly pull up on the injector shield until the injector shield covers the needle all the way. Interferons and efavirenz can both cause hepatotoxicity.
Interferon beta-1a-induced hematologic toxicity is dose related. It may be possible for your doctor to prescribe you a shorter and thinner needle depending on your body type. Interferon beta-1a is administered by intramuscular IM or subcutaneous SC injection depending upon the product. Check the display window and make sure the Avonex is clear and colorless.
Premedication with acetaminophen or ibuprofen may lessen the severity of flu-like symptoms.
The buttock is not a suitable site for injection. The indicated dose is based on data suggesting that early initiation of interferon beta-1a therapy delays the onset of clinically definite MS in high-risk patients who have recently experienced a demyelinating event but do not yet have clinical MS. Abortifacient activity, menstrual irregularities, anovulation, and decreased serum progesterone levels have been observed in some animal studies, including studies in rhesus monkeys, during high dose use.
You may need urgent medical attention. Swelling of the face, lips, mouth or throat which may cause difficulty in swallowing or breathing.
Interrupt telbivudine if peripheral neuropathy is suspected, and insrt the drug if peripheral neuropathy is confirmed. Hold the Avonex Pen with the glass syringe tip pointing up.
Prefilled syringes do not contain preservatives and are single-use only. In relapsing forms of MS, people have ‘exacerbations’ from time to time e. The plastic needle cover will pop off after the injector shield has been fully extended. A long-term follow-up assessment was conducted at year 7 or 8 from the original PRISMS trial; data were available for of the patients and of the were still taking interferon beta-1a subcutaneously 3 times weekly.
In 5 years time, the Rebif Pregnancy Registry only enrolled 36 exposed patients, and the Rebif Pregnancy Registry was closed in early ; the data of the study have been reported but firm conclusions cannot be drawn due to the low enrollment. Tell your doctor, nurse or pharmacist if you notice any of the following and they worry you:.
Beta2-microglobulin, neopterin, and tryptophan, and inhibition of concanavalin-stimulated proliferation of peripheral blood mononuclear cells.
Sodium phosphate monobasic and dibasic.
Bictegravir; Emtricitabine; Tenofovir Alafenamide: Be sure the amount of liquid in the syringe is the same or very close to the 0. Autoimmune disease of multiple target organs has been reported during interferon beta-1a therapy, including idiopathic thrombocytopenia, thyroid disease hyperthyroidism or hypothyroidismand pqckage cases of autoimmune hepatitis.
If you forget to use it If it is less than 2 days before your next injection, skip the dose you missed and have your next injection when you are meant to. Doses of 60 mcg IM once weekly do not provide any additional benefits versus the 30 mcg dose. Use appropriate aseptic technique for preparation of solution.
Do not push down on the injector shield and the blue inserg button at the same time until you are ready to give injection. Patients with a history of depression 2 weeks prior to starting interferon beta-1a therapy may be at increased risk for developing depression during the first 2 months of therapy.
Allergic reactions, including anaphylaxis have been reported with interferon beta-1a use.
Lamivudine; Tenofovir Disoproxil Fumarate: However, a small number of nursing mothers receiving interferon beta-1a reported no adverse effects in their partially breast-fed infants, and the amount of interferon beta-1a excreted into packagr milk appeared to be insignificant.